Research Authors

Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Moderately Good
Based on 11 Reviews
7.9
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Zinc (from 405 mg Zinc Gluconate)
50 mg
455%

Top Medical Research Studies

We set out to investigate how zinc might help protect heart cells from damage caused by a lack of blood flow, known as myocardial ischemia-reperfusion injury (MIRI). Using H9C2 cells, which are derived from rat heart tissue, we simulated this injury by depriving these cells of oxygen and then reintroducing it while treating them with zinc.

Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.

Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.

Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.
Read More
We explored the relationship between atrial natriuretic peptide (ANP) and zinc, particularly how they work together to protect the heart during reperfusion after ischemia. The study involved comparing various experimental rats and mice, as well as assessing plasma samples from patients experiencing heart-related conditions.

Our findings highlighted that ANP significantly boosts zinc levels during the crucial period of reperfusion. This increase in zinc appears to protect heart cells from damage by helping to maintain mitochondrial health, effectively reducing the size of heart tissue injuries. We observed that when ANP was administered alone, it improved heart function, but combining it with a substance that removes zinc led to poorer outcomes.

We also noted that ANP works through a specific signaling pathway (the PI3K pathway) to decrease levels of a zinc transporter, ZnT8, which is upregulated during reperfusion injury. Interestingly, both ANP and zinc had a role in regulating important proteins linked to heart health. Overall, our research suggests that managing zinc levels through ANP treatment can help shield the heart from the harsh effects of ischemia/reperfusion injury.
Read More
We investigated how zinc levels may influence sleep duration in patients with cardiovascular diseases (CVDs). Our study included 150 participants from the Ravansar Non-Communicable Disease Cohort Study, where we measured serum concentrations of zinc and other elements, including essential minerals and toxic metals.

A significant finding was that we observed a strong correlation between higher zinc concentrations and optimal sleep duration. Specifically, the data indicated that as zinc levels increased, the likelihood of achieving an appropriate sleep duration of 7 to 8 hours also increased.

However, when we looked deeper into the data, we did not find significant differences in the serum concentrations of both essential and toxic elements across different sleep duration categories. This suggests that while zinc may play a role in regulating sleep duration, it does not entirely account for sleep issues among CVD patients.

Ultimately, our results encourage further exploration of zinc's impact, particularly as it relates to sleep quality and overall health in individuals with cardiovascular conditions.
Read More

Most Useful Reviews

7.5
Effective treatment
53 people found this helpful
I take it for preventing and treating viral diseases, and it has been effective. It's unfortunate that this dosage became unavailable in Russia.
Read More
7.5
Prevents illness
1 people found this helpful
Zinc is essential for men, particularly for sperm production. It boosts immunity and helps prevent various diseases. I take one tablet each morning, and I haven't suffered from a cold or illness since starting it; I believe it really works.
Read More
7.5
Boosts immune health
1 people found this helpful
Now Foods Zinc is my preferred choice for immune system health and overall well-being. This product has become essential in my daily routine, particularly when I need to enhance my immunity. Each tablet contains 50 mg of zinc, providing my body with this important trace element. I believe zinc aids in protecting my immune system against viruses and diseases, especially in winter. It also helps maintain healthy skin and hair, making it invaluable for my overall health. The tablets are easy to take, and I highly recommend them to anyone seeking reliable support for their immunity.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
  • All Researches
9
Zinc nanoparticles reduce heart damage
We focused our research on how zinc oxide nanoparticles (ZnONPs) might help reduce heart damage caused by cisplatin, a well-known chemotherapy drug. In this study, we used rats divided into different groups, some receiving varying doses of ZnONPs and others serving as control groups.

Our findings indicated that as the dosage of ZnONPs increased up to 50 mg/kg, there was a marked improvement in cardiovascular markers. We observed reduced levels of oxidative stress, inflammation, and cell damage in the heart tissues of those treated with ZnONPs. More specifically, measures related to heart tissue health and serum biomarkers showed that rats receiving higher doses exhibited recovery similar to that of healthy rats.

Overall, we concluded that ZnONPs serve as a protective agent against cisplatin-induced cardiotoxicity, showcasing their potential in improving heart health during cancer treatment.
Read More
We set out to investigate how zinc might help protect heart cells from damage caused by a lack of blood flow, known as myocardial ischemia-reperfusion injury (MIRI). Using H9C2 cells, which are derived from rat heart tissue, we simulated this injury by depriving these cells of oxygen and then reintroducing it while treating them with zinc.

Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.

Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.

Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.
Read More
We explored the relationship between atrial natriuretic peptide (ANP) and zinc, particularly how they work together to protect the heart during reperfusion after ischemia. The study involved comparing various experimental rats and mice, as well as assessing plasma samples from patients experiencing heart-related conditions.

Our findings highlighted that ANP significantly boosts zinc levels during the crucial period of reperfusion. This increase in zinc appears to protect heart cells from damage by helping to maintain mitochondrial health, effectively reducing the size of heart tissue injuries. We observed that when ANP was administered alone, it improved heart function, but combining it with a substance that removes zinc led to poorer outcomes.

We also noted that ANP works through a specific signaling pathway (the PI3K pathway) to decrease levels of a zinc transporter, ZnT8, which is upregulated during reperfusion injury. Interestingly, both ANP and zinc had a role in regulating important proteins linked to heart health. Overall, our research suggests that managing zinc levels through ANP treatment can help shield the heart from the harsh effects of ischemia/reperfusion injury.
Read More
We investigated how zinc levels may influence sleep duration in patients with cardiovascular diseases (CVDs). Our study included 150 participants from the Ravansar Non-Communicable Disease Cohort Study, where we measured serum concentrations of zinc and other elements, including essential minerals and toxic metals.

A significant finding was that we observed a strong correlation between higher zinc concentrations and optimal sleep duration. Specifically, the data indicated that as zinc levels increased, the likelihood of achieving an appropriate sleep duration of 7 to 8 hours also increased.

However, when we looked deeper into the data, we did not find significant differences in the serum concentrations of both essential and toxic elements across different sleep duration categories. This suggests that while zinc may play a role in regulating sleep duration, it does not entirely account for sleep issues among CVD patients.

Ultimately, our results encourage further exploration of zinc's impact, particularly as it relates to sleep quality and overall health in individuals with cardiovascular conditions.
Read More
7
Zinc's role in cardiovascular risk
We explored the relationship between dietary zinc intake and the risk of atherosclerotic cardiovascular disease (ASCVD) in patients with diabetes mellitus (DM). Utilizing data from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2018, we calculated the 10-year ASCVD risk according to established clinical guidelines. Our analysis focused on dietary zinc intake based on food recall data from the participants.

The findings suggest that sufficient dietary zinc intake could positively influence cardiovascular health in diabetes patients. This is particularly important, as diabetes is closely linked with increased oxidative stress and inflammation, two factors that contribute to the development of heart disease. While we see an association between zinc and improved heart health, it's essential to note that further research is needed. Large-scale, well-designed prospective studies should aim to clarify the specific role of zinc in this context.

Overall, our results underscore the potential benefits of zinc for cardiovascular health, particularly in individuals managing diabetes. As we delve deeper into these associations, we aim to provide clearer guidance on how dietary choices can impact health outcomes for those living with diabetes.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 11 Reviews
7.9
  • All Reviews
  • Positive Reviews
  • Negative Reviews
7.5
Effective treatment
53 people found this helpful
I take it for preventing and treating viral diseases, and it has been effective. It's unfortunate that this dosage became unavailable in Russia.
Read More
7.5
Prevents illness
1 people found this helpful
Zinc is essential for men, particularly for sperm production. It boosts immunity and helps prevent various diseases. I take one tablet each morning, and I haven't suffered from a cold or illness since starting it; I believe it really works.
Read More
7.5
Boosts immune health
1 people found this helpful
Now Foods Zinc is my preferred choice for immune system health and overall well-being. This product has become essential in my daily routine, particularly when I need to enhance my immunity. Each tablet contains 50 mg of zinc, providing my body with this important trace element. I believe zinc aids in protecting my immune system against viruses and diseases, especially in winter. It also helps maintain healthy skin and hair, making it invaluable for my overall health. The tablets are easy to take, and I highly recommend them to anyone seeking reliable support for their immunity.
Read More
7.5
Strengthens the body
1 people found this helpful
This zinc has a good composition and dosage. If you seek an effective way to support your immune system, this is a fantastic choice. Zinc is essential for strengthening the body, notably during times of increased disease risk. After taking it, I felt a surge of strength and an improvement in my overall well-being.
Read More
7.5
Profitable zinc choice
1 people found this helpful
Everyone needs zinc. I appreciate this company for providing numerous tablets at a good dosage, especially at a reduced price. Our family takes zinc regularly for protection against viruses, as it helps the illness pass easily. I highly recommend it.
Read More

Frequently Asked Questions

6
Endurance in diseases
1 people found this helpful
We consume zinc during the season; it helps us endure diseases more easily or not get sick at all. I recommend it.
7.5
Prevents illness
1 people found this helpful
Zinc is essential for men, particularly for sperm production. It boosts immunity and helps prevent various diseases. I take one tablet each morning, and I haven't suffered from a cold or illness since starting it; I believe it really works.
7.5
No more colds
64 people found this helpful
Strengthening immunity during colds After the illness with the new coronavirus, the doctor advised me to take a zinc supplement for six months. The illness was mild, lasting three weeks with a temperature of 37-38°C, bed rest, and loss of smell and taste, which eventually returned. The doctor explained that zinc boosts immunity in adults, so I can take it as a precaution from autumn through to spring. However, it is not suitable for children. Additionally, I was prescribed vitamin C for one month and vitamin D3 for six months. Since recovery, I have not experienced any more colds after three months. I trust that the vitamins and zinc have made a difference. I take it in the morning after breakfast to avoid nausea.
7.5
Hair recovery support
1 people found this helpful
These zinc tablets are great for supporting the immune system as well as hair and nails. My family, including my aunt and mother, took them, and they significantly improved my aunt’s hair loss after her surgery. While it won't make you invincible, it certainly aids in maintaining health for longer. The tablets are gentle on the stomach, making them suitable for those with stomach issues.
7.5
Boosts immune health
1 people found this helpful
Now Foods Zinc is my preferred choice for immune system health and overall well-being. This product has become essential in my daily routine, particularly when I need to enhance my immunity. Each tablet contains 50 mg of zinc, providing my body with this important trace element. I believe zinc aids in protecting my immune system against viruses and diseases, especially in winter. It also helps maintain healthy skin and hair, making it invaluable for my overall health. The tablets are easy to take, and I highly recommend them to anyone seeking reliable support for their immunity.
6
Maintains immunity
1 people found this helpful
Zinc chelate is excellent for better absorption. We take it regularly to maintain immunity during the off-season and help alleviate viral diseases. It notably improves my body’s resistance.
7
Zinc's role in cardiovascular risk
We explored the relationship between dietary zinc intake and the risk of atherosclerotic cardiovascular disease (ASCVD) in patients with diabetes mellitus (DM). Utilizing data from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2018, we calculated the 10-year ASCVD risk according to established clinical guidelines. Our analysis focused on dietary zinc intake based on food recall data from the participants.

The findings suggest that sufficient dietary zinc intake could positively influence cardiovascular health in diabetes patients. This is particularly important, as diabetes is closely linked with increased oxidative stress and inflammation, two factors that contribute to the development of heart disease. While we see an association between zinc and improved heart health, it's essential to note that further research is needed. Large-scale, well-designed prospective studies should aim to clarify the specific role of zinc in this context.

Overall, our results underscore the potential benefits of zinc for cardiovascular health, particularly in individuals managing diabetes. As we delve deeper into these associations, we aim to provide clearer guidance on how dietary choices can impact health outcomes for those living with diabetes.
We explored the relationship between atrial natriuretic peptide (ANP) and zinc, particularly how they work together to protect the heart during reperfusion after ischemia. The study involved comparing various experimental rats and mice, as well as assessing plasma samples from patients experiencing heart-related conditions.

Our findings highlighted that ANP significantly boosts zinc levels during the crucial period of reperfusion. This increase in zinc appears to protect heart cells from damage by helping to maintain mitochondrial health, effectively reducing the size of heart tissue injuries. We observed that when ANP was administered alone, it improved heart function, but combining it with a substance that removes zinc led to poorer outcomes.

We also noted that ANP works through a specific signaling pathway (the PI3K pathway) to decrease levels of a zinc transporter, ZnT8, which is upregulated during reperfusion injury. Interestingly, both ANP and zinc had a role in regulating important proteins linked to heart health. Overall, our research suggests that managing zinc levels through ANP treatment can help shield the heart from the harsh effects of ischemia/reperfusion injury.
We explored how zinc deficiency relates to cardiovascular disease among obese adults in Serbia. By conducting a case-control study with 31 obese participants and 31 control subjects, we set out to understand how zinc affects body weight, lipid levels, and inflammation.

Our findings revealed that obese individuals had significantly lower serum zinc levels compared to those who weren't obese. We observed notable negative correlations between zinc levels and various health metrics, including body weight, body fat percentage, and triglycerides.

On the flip side, higher zinc levels correlated positively with beneficial high-density lipoproteins. Interestingly, we noted that the atherosclerotic index was significantly linked to zinc, suggesting that zinc status could play a role in assessing cardiovascular risk in obese individuals.

While this study spotlights zinc's intriguing relationship with cardiovascular risk factors, it does not specifically evaluate the benefits of zinc treatment on cardiovascular outcomes.
7
Zinc's role in heart health
In our exploration of the effects of zinc on cardiovascular health, we examined how the metallothionein (MT) gene influences heart remodeling linked to obesity. Using a mouse model fed a high-fat diet (HFD), we observed that the deletion of the MT gene intensified obesity and its related cardiac issues, such as inflammation and hypertrophy.

Highlighting the role of zinc, we found that it can help counteract these negative changes. Zinc supplementation led to an increase in MT levels, which appeared to protect against the exaggerated effects of HFD. When we looked closer, mice without the MT gene showed heightened activation of the CARD9 and BCL10 proteins, which are associated with inflammation and cardiac remodeling.

This study indicates that zinc not only supports the regulation of trace metals in the body but may also play a crucial protective role against the cardiac damage caused by obesity. In fact, it seems that zinc could be an essential ally in managing cardiovascular risks linked to high-fat diets and obesity-related inflammation.

References

  1. Lyu X, Chen L, Wang W. Dietary zinc intake and 10-year atherosclerotic cardiovascular disease risk in diabetes mellitus patients: evidence from NHANES database. Thromb J. 2025;23:18. 10.1186/s12959-025-00693-0
  2. Ma YT, Laga T, Zhong CN, Zhuang BQ, Quan HL, et al. ANP Increases Zn Accumulation During Reperfusion in Ex Vivo and In Vivo Hearts. Curr Med Sci. 2025;45:35. 10.1007/s11596-025-00019-1
  3. Al-Lbban AM. Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats. Braz J Biol. 2025;84:e287764. 10.1590/1519-6984.287764
  4. Soskic S, Gluvic Z, Obradovic M, Ilincic B, Cabarkapa V, et al. A pilot study on the relationship between zinc deficiency and anthropometric and metabolic parameters in obese adults in Serbia. Scand J Clin Lab Invest. 2025;85:51. 10.1080/00365513.2025.2460034
  5. Zhang H, Zhou W, Wang X, Men H, Wang J, et al. Exacerbation by knocking-out metallothionein gene of obesity-induced cardiac remodeling is associated with the activation of CARD9 signaling. Int J Biol Sci. 2025;21:1032. 10.7150/ijbs.105513
  6. Guo J, Ma T, Wang B, Xing B, Huang L, et al. Zn protects H9C2 cardiomyocytes by alleviating MAMs-associated apoptosis and calcium signaling dysregulation. Cell Signal. 2025;127:111629. 10.1016/j.cellsig.2025.111629
  7. Azadi NA, Nakhaee S, Hassan NE, Mansouri B, Ariyaee M. Role of toxic and essential elements in sleep duration of patients with cardiovascular diseases. Sci Rep. 2025;15:2392. 10.1038/s41598-025-86873-4
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